More gore and guns, with nicer hairy werewolves. The plot thickens a bit, but since nearly all characters die (even the main ones, which come back again), everything is self-contained.
Selene is a daywalker now, after sucking Derek Jacobi, old man Corvinus. Corvinus is dead, and so is his team. The elder descendants are dead too, and also the vampire clans. Loads of werewolves still come up somehow.
Just like the last time, Selene and the hybrid walk into the sunrise without knowing what comes next.